Escaping Death: Mitochondrial Redox Homeostasis in Cancer Cells
نویسندگان
چکیده
منابع مشابه
Escaping Death: Mitochondrial Redox Homeostasis in Cancer Cells
Reactive oxygen species (ROS) are important signaling molecules that act through the oxidation of nucleic acids, proteins, and lipids. Several hallmarks of cancer, including uncontrolled proliferation, angiogenesis, and genomic instability, are promoted by the increased ROS levels commonly found in tumor cells. To counteract excessive ROS accumulation, oxidative stress, and death, cancer cells ...
متن کاملRedox Homeostasis in Pancreatic β Cells
We reviewed mechanisms that determine reactive oxygen species (redox) homeostasis, redox information signaling and metabolic/regulatory function of autocrine insulin signaling in pancreatic β cells, and consequences of oxidative stress and dysregulation of redox/information signaling for their dysfunction. We emphasize the role of mitochondrion in β cell molecular physiology and pathology, incl...
متن کاملEnergy and Redox Homeostasis in Tumor Cells
Cancer cells display abnormal morphology, chromosomes, and metabolism. This review will focus on the metabolism of tumor cells integrating the available data by way of a functional approach. The first part contains a comprehensive introduction to bioenergetics, mitochondria, and the mechanisms of production and degradation of reactive oxygen species. This will be followed by a discussion on the...
متن کاملEscaping death to quiescence
Cancer recurrence is associated with treatment failure and is the main cause of death, 1 and thus remains to be a major clinical challenge. elevated level of the cyclin-dependent kinase 1 (CDK1) correlates with cancer recurrence and treatment resistance in patients with breast cancer or colorectal cancer. 2,3 it is proposed that defects in CDKs may lead to the accumulated genetic defects, which...
متن کاملNAC selectively inhibit cancer telomerase activity: A higher redox homeostasis threshold exists in cancer cells
Telomerase activity controls telomere length, and this plays an important role in stem cells, aging and tumors. Antioxidant was shown to protect telomerase activity in normal cells but inhibit that in cancer cells, but the underlying mechanism is elusive. Here we found that 7721 hepatoma cells held a higher redox homeostasis threshold than L02 normal liver cells which caused 7721 cells to have ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Oncology
سال: 2017
ISSN: 2234-943X
DOI: 10.3389/fonc.2017.00117